Priyadarshini Pathak
Education
Ph.D. Chemistry. Specialization in chemical biology, 2012
Graduate Program in Chemistry, Stony Brook University, Stony Brook, NY
M.Sc. Analytical Chemistry, 2001
MES’ Abasaheb Garware College, University of Pune, Pune, India
B.Sc. Chemistry, with Minors in: Physics, Botany and Zoology, 1999
MES’ Abasaheb Garware College, University of Pune, Pune, India
Student Research/Collaboration
- Designing lipophilic organic-salt nanoparticles for selectively targeting cancer cells.
- Mechanism of plasma membrane interaction of lipophilic organic salt based nanoparticles.
- Study of Nanodomain (Lipid Raft) Formation and effect of Triton X-100 and peptides on lipid raft size in Membranes.
- Study of membrane lipid composition on formation of lipid raft nanodomains
- Detection of membrane nanodomains in living Borrelia burgdorferi cells.
- Determination of effect of membrane lipid composition on raft size.
Publications
- Pathak P and London E. (2015) The Effect of Membrane Lipid Composition Upon the Formation of Lipid Ultrananodomains. Biophysical Journal 109 (8) (1630-1638).
- Pathak P*, LaRocca TJ*, Chiantia S, Toledo A, Dastgheib-Behesti K, Silvius JR, Benach JL and London E. (* Equal contribution) (2013). Proving lipid rafts exist: membrane domains in the prokaryote Borreliaburgdorferi have the same properties as eukaryotic lipid rafts. PLOS Pathogens 9 (1-11).
- Pathak P and London E (2011). Measurement of Lipid Nanodomain (Raft) Formation and Size in Sphingomyelin/POPC/Cholesterol Vesicles Shows TX-100 and Transmembrane Helices Increase Domain Size by Coalescing Pre-Existing Nanodomains But Do Not Induce Domain Formation. Biophysical Journal 101 (2417- 2425).
- LaRocca TJ, Crowley JT, Cusack BJ, Pathak P, Benach J, London E, Garcia-Monco JC and Benach JL. (2010). Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody. Cell Host Microbe 8 (331-342).
- Omar Bakht, Pathak P and London E. (2007). Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): Identification of multiple raft- stabilization mechanisms. Biophysical Journal 93 (4307-4318).